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KMID : 0900920010250020139
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Korean journal of Animal Reproduction
2001 Volume.25 No. 2 p.139 ~ p.145
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Studies on Effects of Consecutive Lead-Administration on Feed, Water Intake, Weight Gain, Blood Pictures and Mineral Level of Organ in Rats
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Kim Sang-Keun
Lee Myoung-Heon
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Abstract
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This study was performed to elucidate the patho-physiology of lead acetate-poisoned rats after consecutive oral administrations of the lead. The changes in feed and water intake, gains of body weight, blood pictures and mineral compositions of several organs were observed to measure the effects of lead acetate-poisoning. 1. Compared with control group, every experimental group of which 1,000, 2,000, or 4,000 ppm/kg of lead acetate was administered displayed a gradual decrease in feed intake in dose-dependent manners. 2. After 1,000, 2,000 or 4,000 ppm/kg of lead acetate administration, water intake seemed to decrease in every experimental group in dose-dependent manners. 3. After 1,000, 2,000 or 4,000 ppm/kg of lead acetate administration, body weight decreased in every experimental group in dose-dependent manners. 4. After 1000, 2,000 or 4,000 ppm/kg of lead acetate administration, the PLT values and numbers of RBC and WBC significantly increased after lead acetate administration, but the values of Hb and PCV were lower than those of control group′s. 5. After 2,000 or 4,000 ppm/kg of lead acetate administration, the levels of Pb, Mn, Fe, Pb and Zn in the livers were lowered, but the levels of Pb, Mn, Fe, Pb and Zn in the kidneys.
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